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Article

Cisplatin-induced ototoxicity in organotypic cochlear cultures occurs independent of gap junctional intercellular communication.

Cell death & disease - 11 May 2020

Abitbol Julia, Beach Rianne, Barr Kevin, Esseltine Jessica, Allman Brian, Laird Dale

Abstract excerpt

Cisplatin is a very effective chemotherapeutic, but severe and permanent hearing loss remains a prevalent side effect. The processes underpinning cisplatin-induced ototoxicity are not well understood. Gap junction channels composed of connexin (Cx) subunits allow for the passage of small molecules and ions between contacting neighboring cells. These specialized channels have been postulated to enhance...

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Identifiers

PMID: 32393745
DOI: 10.1038/s41419-020-2551-8
PMCID: PMC7214471

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