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Article

Expression of 8-oxoguanine Glycosylase in Human Fetal Membranes

3 Mar 2014

Abstract excerpt

PROBLEM: The most common DNA lesion generated by oxidative stress (OS) is 7, 8-dihydro-8-oxoguanine (8-oxoG) whose excision repair is performed by 8-oxoguanine glycosylase (OGG1). We investigated OGG1 expression changes in fetal membranes from spontaneous preterm birth (PTB) and preterm premature rupture of the membranes (pPROM) and its changes in vitro in normal fetal membranes exposed to OS inducer...

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PMID: 24589083
DOI: 10.1111/aji.12220

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