Article

Exome sequencing identifies ARID2 as a novel tumor suppressor in early-onset sporadic rectal cancer

2020-04-16

Abstract excerpt

Early-onset sporadic rectal cancer (EOSRC) is a unique and predominant colorectal cancer (CRC) subtype in India. In order to understand the tumorigenic process in EOSRC, we performed whole exome sequencing of 47 microsatellite stable EOSRC samples. Signature 1 was the predominant mutational signature in EOSRC, as previously shown in other CRC exome studies. More importantly, we identified TP53, KRAS, APC, PIK3R1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 29ef1391-c4d6-5bbb-84bc-4c4c47b03e86
DOI: 10.1101/2020.04.15.040741

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exome sequencing identifies ARID2 as a novel tumor suppressor in early-onset sporadic rectal cancerDOI 10.1101/2020.04.15.040741Read

Exome sequencing identifies ARID2 as a novel tumor suppressor in early-onset sporadic rectal cancer.Semantic proximity Read

Roles of ARID1A variations in colorectal cancer: a collaborative reviewSemantic proximity Read

Integrated clinicopathological and mutational profiling accumulates histological characteristics of rare and conventional colorectal cancer in Indian patientsSemantic proximity Read

Comprehensive genomic profiling reveals prognostic signatures and insights into the molecular landscape of colorectal cancerSemantic proximity Read

The impact of ARID1A mutation on molecular characteristics in colorectal cancer.Semantic proximity Read

Comprehensive molecular characterization of human colon and rectal cancer.Semantic proximity Read

Decoding Early-Onset of Colorectal Cancer: Insights into SERPINA3 Expression PatternsSemantic proximity Read

Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer.Semantic proximity Read

ARID2 loss destabilizes PBAF and drives colorectal cancerSemantic proximity Read

Exploring the Role of Non-synonymous and Deleterious Variants Identified in Colorectal Cancer: A Multi-dimensional Computational Scrutiny of ExomesSemantic proximity Read

Exome-wide somatic mutation characterization of small bowel adenocarcinoma.Semantic proximity Read

ARID1A mutations in cancer development: mechanism and therapy.Semantic proximity Read