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Metabolic and reproductive consequences of the serotonin transporter promoter polymorphism (5-HTTLPR) in adult female rhesus monkeys (Macaca mulatta).

Endocrine - 1 Apr 2007

Hoffman J B, Kaplan J R, Kinkead B, Berga S L, Wilson M E

Abstract excerpt

The serotonin (5HT) reuptake transporter (SERT) plays a key role in 5HT homeostasis by recycling 5HT into the presynaptic neurons. Recently, polymorphisms in the length of the promoter region of the gene that encodes SERT have been linked to functional differences in reactivity to psychosocial stress, as the short (s) promoter length allele shows reduced transcriptionally activity in vitro and is associated with...

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PMID: 17873333
DOI: 10.1007/s12020-007-0017-8

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