Article
Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates.
Archives of general psychiatry - 1 Nov 2004
Barr Christina S, Newman Timothy K, Lindell Stephen, Shannon Courtney, Champoux Maribeth, Lesch Klaus Peter, Suomi Stephen J, Goldman David, Higley J Dee
Abstract excerpt
BACKGROUND: Serotonin neurotransmission and limbic-hypothalamic-pituitary-adrenal (LHPA) axis hormones are thought to be involved in the reinforcement of alcohol intake and contribute to the risk for alcoholism. In humans and macaques, a promoter polymorphism that decreases transcription of the serotonin transporter gene is associated with anxiety and altered LHPA-axis responses to stress, and in female macaques,...
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