Article
The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus macaque brain: potential roles in genetic selection and gene × environment interactions.
Development and psychopathology - 1 Nov 2012
Lindell Stephen G, Yuan Qiaoping, Zhou Zhifeng, Goldman David, Thompson Robert C, Lopez Juan F, Suomi Stephen J, Higley J Dee, Barr Christina S
Abstract excerpt
In humans, it has been demonstrated that the serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates risk in the face of adversity. One mechanism by which stress could interact with genotype is via epigenetic modifications. We wanted to examine whether stress interacted with genotype to predict binding of a histone 3 protein trimethylated at lysine 3 (H3K4me3) that marks active promoters....
Topics
- Age Factors
- Animals
- Behavior, Animal
- Epigenesis, Genetic
- Gene-Environment Interaction
- Genotype
- Hippocampus
- Histones
- Hydroxyindoleacetic Acid
- Macaca mulatta