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Article

A mechanism linking Id2-TGFβ crosstalk to reversible adaptive plasticity in neuroblastoma.

PloS one - 1 Jan 2013

Chakrabarti Lina, Wang Bi-Dar, Lee Norman H, Sandler Anthony D

Abstract excerpt

The ability of high-risk neuroblastoma to survive unfavorable growth conditions and multimodal therapy has produced an elusive childhood cancer with remarkably poor prognosis. A novel phenomenon enabling neuroblastoma to survive selection pressure is its capacity for reversible adaptive plasticity. This plasticity allows cells to transition between highly proliferative anchorage dependent (AD) and slow growing,...

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Identifiers

PMID: 24376712
DOI: 10.1371/journal.pone.0083521
PMCID: PMC3871549

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