Article
Mesenchymal change and drug resistance in neuroblastoma.
The Journal of surgical research - 1 Jan 2015
Naiditch Jessica A, Jie Chunfa, Lautz Timothy B, Yu Songtao, Clark Sandra, Voronov Dimitry, Chu Fei, Madonna Mary Beth
Abstract excerpt
BACKGROUND: Metastatic initiation has many phenotypic similarities to epithelial-to-mesenchymal transition, including loss of cell-cell adhesion, increased invasiveness, and increased cell mobility. We have previously demonstrated that drug resistance is associated with a metastatic phenotype in neuroblastoma (NB). The purpose of this project was to determine if the development of doxorubicin resistance is...
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