Article
MicroRNAs define distinct human neuroblastoma cell phenotypes and regulate their differentiation and tumorigenicity.
BMC cancer - 2 May 2014
Samaraweera Leleesha, Grandinetti Kathryn B, Huang Ruojun, Spengler Barbara A, Ross Robert A
Abstract excerpt
BACKGROUND: Neuroblastoma (NB) is the most common extracranial solid tumor in children. NB tumors and derived cell lines are phenotypically heterogeneous. Cell lines are classified by phenotype, each having distinct differentiation and tumorigenic properties. The neuroblastic phenotype is tumorigenic, has neuronal features and includes stem cells (I-cells) and neuronal cells (N-cells). The non-neuronal phenotype...
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