Article
Use of net reclassification improvement (NRI) method confirms the utility of combined genetic risk score to predict type 2 diabetes.
PloS one - 1 Jan 2013
Tam Claudia H T, Ho Janice S K, Wang Ying, Lam Vincent K L, Lee Heung Man, Jiang Guozhi, Lau Eric S H, Kong Alice P S, Fan Xiaodan, Woo Jean L F, Tsui Stephen K W, Ng Maggie C Y, So Wing Yee, Chan Juliana C N, Ma Ronald C W
Abstract excerpt
BACKGROUND: Recent genome-wide association studies (GWAS) identified more than 70 novel loci for type 2 diabetes (T2D), some of which have been widely replicated in Asian populations. In this study, we investigated their individual and combined effects on T2D in a Chinese population. METHODOLOGY:...
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