Article
Evidence that the LRRK2 ROC domain Parkinson's disease-associated mutants A1442P and R1441C exhibit increased intracellular degradation.
Journal of neuroscience research - 1 Apr 2014
Greene Izabella D, Mastaglia Francis, Meloni Bruno P, West Kristin A, Chieng Joanne, Mitchell Chris J, Gai Wei-Ping, Boulos Sherif
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (lrrk2) gene are the leading genetic cause of Parkinson's disease (PD). In characterizing the novel ROC domain mutant A1442P, we compared its steady-state protein levels, propensity to aggregate, and toxicity with the pathogenic R1441C mutant and wild-type (WT) LRRK2. Mutant (R1441C and A1442P) and WT LRRK2 fused to green fluorescent protein (GFP) and FLAG were...
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