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Article

Estrogen receptor α in cancer-associated fibroblasts suppresses prostate cancer invasion via modulation of thrombospondin 2 and matrix metalloproteinase 3.

Carcinogenesis - 1 Jun 2014

Slavin Spencer, Yeh Chiuan-Ren, Da Jun, Yu Shengqiang, Miyamoto Hiroshi, Messing Edward M, Guancial Elizabeth, Yeh Shuyuan

Abstract excerpt

The prostate cancer (PCa) microenvironment contains active stromal cells known as cancer-associated fibroblasts (CAF) that may play important roles in influencing tumor progression. Here we studied the role of CAF estrogen receptor alpha (ERα) and found that it could protect against PCa invasion....

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Source

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Identifiers

PMID: 24374826
DOI: 10.1093/carcin/bgt488
PMCID: PMC4043239

Genes

MMP3
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24374826-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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