A pro‐tumourigenic loop at the human prostate tumour interface orchestrated by oestrogen, <scp>CXCL12</scp> and mast cell recruitment

Abstract excerpt

Prostate cancer is hormone-dependent and regulated by androgens as well as oestrogens. The tumour microenvironment also provides regulatory control, but the balance and interplay between androgens and oestrogens at the human prostate tumour interface is unknown. This study reveals a central and dominant role for oestrogen in the microenvironment, fuelling a pro-tumourigenic loop of inflammatory cytokines...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Estrogen and related hormone effects
• Share to Mast cells and histamine
• Share to Prostate Cancer Treatment and Research