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Article

SOX9 in prostate cancer is upregulated by cancer‐associated fibroblasts to promote tumor progression through HGF/c‐Met‐FRA1 signaling

11 Mar 2021

Abstract excerpt

Transcription factor SOX9 was a biomarker for prostate cancer (Pca) with poor prognosis. Nevertheless, the regulatory mechanism underlying SOX9 upregulation still remains unclear. Several cytokines have been reported to be involved in the regulation of SOX9, suggesting that cancer-associated fibroblasts (CAFs), one of the main sources of secreted factors in the tumor microenvironment (TME), may play a role in...

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PMID: 33705609
DOI: 10.1111/febs.15816

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