Article
Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis.
Cell communication and signaling : CCS - 24 Jan 2020
Neuwirt Hannes, Bouchal Jan, Kharaishvili Gvantsa, Ploner Christian, Jöhrer Karin, Pitterl Florian, Weber Anja, Klocker Helmut, Eder Iris E
Abstract excerpt
BACKGROUND: Androgen receptor targeted therapies have emerged as an effective tool to manage advanced prostate cancer (PCa). Nevertheless, frequent occurrence of therapy resistance represents a major challenge in the clinical management of patients, also because the molecular mechanisms behind therapy resistance are not yet fully understood. In the present study, we therefore aimed to identify novel targets to...
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