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Article

Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.

Cell metabolism - 3 Sept 2013

Satoh Akiko, Brace Cynthia S, Rensing Nick, Cliften Paul, Wozniak David F, Herzog Erik D, Yamada Kelvin A, Imai Shin-Ichiro

Abstract excerpt

The mammalian Sir2 ortholog Sirt1 plays an important role in metabolic regulation. However, the role of Sirt1 in the regulation of aging and longevity is still controversial. Here we demonstrate that brain-specific Sirt1-overexpressing (BRASTO) transgenic mice show significant life span extension in both males and females, and aged BRASTO mice exhibit phenotypes consistent with a delay in aging. These phenotypes...

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Source

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Identifiers

PMID: 24011076
DOI: 10.1016/j.cmet.2013.07.013
PMCID: PMC3794712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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