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Article

SIRT1 accelerates the progression of activity-based anorexia.

Nature communications - 4 Jun 2020

Robinette Timothy M, Nicholatos Justin W, Francisco Adam B, Brooks Kayla E, Diao Rachel Y, Sorbi Sandro, Ricca Valdo, Nacmias Benedetta, Brieño-Enríquez Miguel A, Libert Sergiy

Abstract excerpt

Food consumption is fundamental for life, and eating disorders often result in devastating or life-threatening conditions. Anorexia nervosa (AN) is characterized by a persistent restriction of energy intake, leading to lowered body weight, constant fear of gaining weight, and psychological disturbances of body perception. Herein, we demonstrate that SIRT1 inhibition, both genetically and pharmacologically, delays...

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Identifiers

PMID: 32499508
DOI: 10.1038/s41467-020-16348-9
PMCID: PMC7272424

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