Article
A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes.
Genome research - 1 Mar 2011
Choufani Sanaa, Shapiro Jonathan S, Susiarjo Martha, Butcher Darci T, Grafodatskaya Daria, Lou Youliang, Ferreira Jose C, Pinto Dalila, Scherer Stephen W, Shaffer Lisa G, Coullin Philippe, Caniggia Isabella, Beyene Joseph, Slim Rima, Bartolomei Marisa S, Weksberg Rosanna
Abstract excerpt
Imprinted genes are critical for normal human growth and neurodevelopment. They are characterized by differentially methylated regions (DMRs) of DNA that confer parent of origin-specific transcription. We developed a new strategy to identify imprinted gene-associated DMRs. Using genome-wide methylation profiling of sodium bisulfite modified DNA from normal human tissues of biparental origin, candidate DMRs were...
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