Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations.

doi:10.1038/gim.2014.46

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Dec 2014

Maeda Toshiyuki, Higashimoto Ken, Jozaki Kosuke, Yatsuki Hitomi, Nakabayashi Kazuhiko, Makita Yoshio, Tonoki Hidefumi, Okamoto Nobuhiko, Takada Fumio, Ohashi Hirofumi, Migita Makoto, Kosaki Rika, Matsubara Keiko, Ogata Tsutomu, Matsuo Muneaki, Hamasaki Yuhei, Ohtsuka Yasufumi, Nishioka Kenichi, Joh Keiichiro, Mukai Tsunehiro, Hata Kenichiro, Soejima Hidenobu

Abstract excerpt

PURPOSE: Expression of imprinted genes is regulated by DNA methylation of differentially methylated regions (DMRs). Beckwith-Wiedemann syndrome is an imprinting disorder caused by epimutations of DMRs at 11p15.5. To date, multiple methylation defects have been reported in Beckwith-Wiedemann syndrome patients with epimutations; however, limited numbers of DMRs have been analyzed. The susceptibility of DMRs to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Beckwith-Wiedemann Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA

Share to DNA Methylation

Share to Gene Expression Profiling

Share to Gene Expression Regulation

Share to Genomic Imprinting

Share to Infant, Newborn

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Open in PubMed Open full text

Identifiers

PMID: 24810686
DOI: 10.1038/gim.2014.46
PMCID: PMC4262761

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations.PMID 24810686Read ↗

Epigenetic and genetic alterations of the imprinting disorder Beckwith-Wiedemann syndrome and related disorders.Semantic proximity Read ↗

Comprehensive molecular and clinical findings in 29 patients with multi-locus imprinting disturbance.Semantic proximity Read ↗

Highly variable genomic methylation in the Beckwith-Wiedemann syndrome associated with Multi-Locus Imprinting DisturbancesSemantic proximity Read ↗

Targeted methylation testing of a patient cohort broadens the epigenetic and clinical description of imprinting disorders.Semantic proximity Read ↗

DNA methylation studies on imprinted loci in a male monozygotic twin pair discordant for Beckwith-Wiedemann syndromeSemantic proximity Read ↗

Genome-wide DNA methylation analysis of patients with imprinting disorders identifies differentially methylated regions associated with novel candidate imprinted genes.Semantic proximity Read ↗

Investigation of Multilocus Imprinting Disturbance (MLID) in 101 Beckwith-Wiedemann Spectrum patientsSemantic proximity Read ↗

The utility of quantitative methylation assays at imprinted genes for the diagnosis of fetal and placental disordersSemantic proximity Read ↗

ImprintSeq, a novel tool to interrogate DNA methylation at human imprinted regions and diagnose multilocus imprinting disturbanceSemantic proximity Read ↗

Aberrant hypomethylation at imprinted differentially methylated regions is involved in biparental placental mesenchymal dysplasiaSemantic proximity Read ↗

Multilocus methylation defects in imprinting disordersSemantic proximity Read ↗

Genome-wide allelic methylation analysis reveals disease-specific susceptibility to multiple methylation defects in imprinting syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.