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Article

Transcriptional regulators Myb and BCL11A interplay with DNA methyltransferase 1 in developmental silencing of embryonic and fetal β‐like globin genes

26 Dec 2013

Abstract excerpt

The clinical symptoms of hemoglobin disorders such as β-thalassemia and sickle cell anemia are significantly ameliorated by the persistent expression of γ-globin after birth. This knowledge has driven the discovery of important regulators that silence γ-globin postnatally. Improved understanding of the γ- to β-globin switching mechanism holds the key to devising targeted therapies for β-hemoglobinopathies. To...

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Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation
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PMID: 24371119
DOI: 10.1096/fj.13-242669

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