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Article

Methyl binding domain protein 2 mediates γ-globin gene silencing in adult human βYAC transgenic mice

11 Apr 2006

Abstract excerpt

The genes of the vertebrate beta-globin locus undergo a switch in expression during erythroid development whereby embryonic/fetal genes of the cluster are sequentially silenced and adult genes are activated. We describe here a role for DNA methylation and MBD2 in the silencing of the human fetal gamma-globin gene. The gamma-globin gene is reactivated upon treatment with the DNA methyltransferase inhibitor...

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Share to Epigenetics and DNA Methylation
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PMID: 16608912
DOI: 10.1073/pnas.0509322103

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Methyl binding domain protein 2 mediates γ-globin gene silencing in adult human βYAC transgenic micePMID 16608912Read ↗

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