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Article

Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta.

Journal of virology - 1 Mar 2014

Thibaut Hendrik Jan, van der Schaar Hilde M, Lanke Kjerstin H W, Verbeken Erik, Andrews Martin, Leyssen Pieter, Neyts Johan, van Kuppeveld Frank J M

Abstract excerpt

Coxsackieviruses require phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) for replication but can bypass this need by an H57Y mutation in protein 3A (3A-H57Y). We show that mutant coxsackievirus is not outcompeted by wild-type virus during 10 passages in vitro. In mice, the mutant virus proved as vi...

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Identifiers

PMID: 24371067
DOI: 10.1128/JVI.03177-13
PMCID: PMC3958056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24371067-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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