Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates.

doi:10.1038/nm0595-433

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Article

Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates.

Nature medicine - 1 May 1995

Beck M A, Shi Q, Morris V C, Levander O A

Abstract excerpt

Previous work from our laboratory demonstrated that selenium deficiency in the mouse allows a normally benign (amyocarditic) cloned and sequenced Coxackievirus to cause significant heart damage. Furthermore, Coxsackievirus recovered from the hearts of selenium-deficient mice inoculated into selen...

Topics

Animals
Biological Evolution
Coxsackievirus Infections
DNA, Viral
Enterovirus B, Human
Heart
Mice
Mice, Inbred C3H
Mutation
Myocarditis
Selenium
Sequence Analysis, DNA
Virulence

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