Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PCR-based testing for therapy-related EGFR mutations in patients with non-small cell lung cancer.

Anticancer research - 1 Jan 2000

Dahse Regine, Berndt Alexander, Kosmehl Hartwig

Abstract excerpt

BACKGROUND: In patients with non-small cell lung cancer (NSCLC), mutations in the epidermal growth factor receptor gene (EGFR) have been associated with improved response to tyrosine kinase inhibitors. Two hotspot mutations located in exon 19 and exon 21 account for about 90% of all EGFR mutations. MATERIALS AND METHODS: We designed a Bi-PASA (bidirectional PCR amplification of specific alleles) assay to detect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung
Share to Cohort Studies
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Genes, erbB-1

Share to Lung Neoplasms

Share to Point Mutation

Source

Identifiers

PMID: 18751405

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PCR-based testing for therapy-related EGFR mutations in patients with non-small cell lung cancer.PMID 18751405Read ↗

Highly sensitive EGFR mutation detection by specific amplification of mutant alleles.Semantic proximity Read ↗

Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas.Semantic proximity Read ↗

Molecular diagnosis of activating EGFR mutations in non-small cell lung cancer using mutation-specific antibodies for immunohistochemical analysis.Semantic proximity Read ↗

Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer.Semantic proximity Read ↗

Novel epidermal growth factor receptor mutation-specific antibodies for non-small cell lung cancer: immunohistochemistry as a possible screening method for epidermal growth factor receptor mutations.Semantic proximity Read ↗

A Comparison of Methods for EGFR Mutation Testing in Non–Small Cell Lung CancerSemantic proximity Read ↗

[Detection of epidermal growth factor receptor gene mutations in non-small cell lung cancer using bi-loop probe specific primer quantitative PCR].Semantic proximity Read ↗

Epidermal growth factor receptor mutations in non-small cell lung cancer undetected by high-sensitivity allele-specific real-time polymerase chain reaction-based assays.Semantic proximity Read ↗

EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment.Semantic proximity Read ↗

Rapid detection of epidermal growth factor receptor mutations in non-small cell lung cancer using real-time polymerase chain reaction with TaqMan-MGB probes.Semantic proximity Read ↗

Detection of EGFR mutations in plasma and biopsies from non-small cell lung cancer patients by allele-specific PCR assays.Semantic proximity Read ↗

Plasma epidermal growth factor receptor mutation testing with a chip-based digital PCR system in patients with advanced non-small cell lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.