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Article

A sensitive method for detecting EGFR mutations in non-small cell lung cancer samples with few tumor cells.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2008

Molina-Vila Miguel A, Bertran-Alamillo Jordi, Reguart Noemí, Taron Miquel, Castellà Eva, Llatjós Mariona, Costa Carlota, Mayo Clara, Pradas Anna, Queralt Cristina, Botia Mónica, Pérez-Cano María, Carrasco Esther, Tomàs Mireia, Mate Jose Luis, Moran Teresa, Rosell Rafael

Abstract excerpt

BACKGROUND: Detection of epidermal growth factor receptor (EGFR) mutations in advanced non-small cell lung cancer (NSCLC) patients has relied on DNA purification from biopsies, amplification, and sequencing. However, the number of tumor cells in a sample is often insufficient for EGFR assessment. METHODS: We prospectively screened 1380 NSCLC patients for EGFR mutations but found that 268 were not evaluable...

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Identifiers

PMID: 18978556
DOI: 10.1097/JTO.0b013e318189f579

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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