Article
Cytomegalovirus infection modulates the phenotype and functional profile of the T-cell immune response to mycobacterial antigens in older life.
Experimental gerontology - 1 Jun 2014
Terrazzini Nadia, Bajwa Martha, Vita Serena, Thomas David, Smith Helen, Vescovini Rosanna, Sansoni Paolo, Kern Florian
Abstract excerpt
Infection with Cytomegalovirus is associated with accelerated immunosenescence. Expansions of CMV-specific T cell responses have previously been demonstrated to affect the ability of T cells to respond to other infections. Most people above 60years of age display M. tuberculosis-specific immunity because of vaccination, exposure, or both. T-cell responses can be assessed by measuring intracellular IFN-γ in vitro...
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