Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size

18 Jan 2016

Abstract excerpt

Cytomegalovirus (CMV) infection is one of the most common persistent viral infections in humans worldwide and is epidemiologically associated with many adverse health consequences during aging. Previous studies yielded conflicting results regarding whether large, CMV-specific T-cell expansions maintain their function during human aging. In the current study, we examined the in vitro CMV-pp65-reactive T-cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Herpesvirus Infections and Treatments
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26778409
DOI: 10.1038/srep19227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response sizePMID 26778409Read ↗

CMV-Specific T-cell Responses at Older Ages: Broad Responses With a Large Central Memory Component May Be Key to Long-term SurvivalSemantic proximity Read ↗

IFNγ⁻TNFα⁻IL2⁻MIP1α⁻CD107a⁺PRF1⁺ CD8 pp65-Specific T-Cell Response Is Independently Associated With Time to Death in Elderly Humans.Semantic proximity Read ↗

CMV induces expansion of highly polyfunctional CD4+ T cell subset coexpressing CD57 and CD154.Semantic proximity Read ↗

Cytomegalovirus and Epstein-Barr virus co-infected young and middle-aged adults can have an aging-related T-cell phenotype.Semantic proximity Read ↗

Perforin and IL-2 Upregulation Define Qualitative Differences among Highly Functional Virus-Specific Human CD8+ T CellsSemantic proximity Read ↗

Long-Term Cytomegalovirus Infection Leads to Significant Changes in the Composition of the CD8<sup>+</sup>T-Cell Repertoire, Which May Be the Basis for an Imbalance in the Cytokine Production Profile in Elderly PersonsSemantic proximity Read ↗

Characterization of Specific Responses to Three Models of Viral Antigens in Immunocompetent Older AdultsSemantic proximity Read ↗

The Polyfunctionality of Human Memory CD8+ T Cells Elicited by Acute and Chronic Virus Infections Is Not Influenced by AgeSemantic proximity Read ↗

The Cytomegalovirus-Specific CD4 + T-Cell Response Expands with Age and Markedly Alters the CD4 + T-Cell RepertoireSemantic proximity Read ↗

CMV Status Drives Distinct Trajectories of CD4+ T Cell DifferentiationSemantic proximity Read ↗

Naïve and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus.Semantic proximity Read ↗

Diverse specificities, phenotypes, and antiviral activities of cytomegalovirus-specific CD8+ T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.