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Seizures, behavioral deficits and adverse drug responses in two new genetic mouse models of <i>HCN1</i> epileptic encephalopathy

2021-08-17

Abstract excerpt

De novo mutations in voltage- and ligand-gated channels have been associated with an increasing number of cases of developmental and epileptic encephalopathies, which often fail to respond to classic antiseizure medications. Here, we examine two knock-in mouse models replicating de novo mutations in the HCN1 voltage-gated channel gene, p.G391D and p.M153I ( Hcn1 G380D/+ and Hcn1 M142I/+ in mouse), associated...

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Identifiers and source

Literature Corpus work
7a2756fa-b0ce-53f0-bbf2-58f70a51b47f
DOI
10.1101/2021.08.16.456452
Open publication

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Seizures, behavioral deficits and adverse drug responses in two new genetic mouse models of <i>HCN1</i> epileptic encephalopathyDOI 10.1101/2021.08.16.456452
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