Article
Presymptomatic spinal cord neurometabolic findings in SOD1-positive people at risk for familial ALS.
Neurology - 4 Oct 2011
Carew J D, Nair G, Andersen P M, Wuu J, Gronka S, Hu X, Benatar M
Abstract excerpt
OBJECTIVE: It has been speculated that amyotrophic lateral sclerosis (ALS) is characterized by a premanifest period during which neurodegeneration precedes the appearance of clinical manifestations. Magnetic resonance spectroscopy (MRS) was used to measure ratios of neurometabolites in the cervical spine of asymptomatic individuals with a mutation in the SOD1 gene (SOD1+) and compare their neurometabolic ratios...
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