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Article

Seven-Tesla proton magnetic resonance spectroscopic imaging in adult X-linked adrenoleukodystrophy.

Archives of neurology - 1 Nov 2008

Ratai Eva, Kok Trina, Wiggins Christopher, Wiggins Graham, Grant Ellen, Gagoski Borjan, O'Neill Gilmore, Adalsteinsson Elfar, Eichler Florian

Abstract excerpt

BACKGROUND: Adults with X-linked adrenoleukodystrophy (X-ALD) remain at risk for progressive neurological deterioration. Phenotypes vary in their pathology, ranging from axonal degeneration to inflammatory demyelination. The severity of symptoms is poorly explained by conventional imaging. OBJECTIVE: To test the hypothesis that neurochemistry in normal-appearing brains differs in adult phenotypes of X-ALD and...

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PMID: 19001168
DOI: 10.1001/archneur.65.11.1488
PMCID: PMC2829763

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