Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MRS in relation to hippocampal volume in the oldest old.

Neurology - 8 Apr 2003

Spencer David C, Zitzelberger Tracy, Spielman Daniel, Kaye Jeffrey

Abstract excerpt

The MRS brain metabolite ratio N-acetylaspartate (NAA)/myo-inositol (mI) is reported to be decreased in AD. MRS was used to study medial temporal and parietal regions in 60 cognitively healthy subjects older than 85 years. Subjects with small hippocampal volumes, a putative risk factor for dementia, had significantly lower NAA/mI in parietal and temporal lobes compared with other subjects. Neuropsychological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Aspartic Acid
Share to Creatine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hippocampus

Share to Inositol

Share to Magnetic Resonance Spectroscopy

Share to Parietal Lobe

Share to Temporal Lobe

Source

Identifiers

PMID: 12682335
DOI: 10.1212/01.wnl.0000052822.22994.86

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

MRS in relation to hippocampal volume in the oldest old.PMID 12682335Read ↗

1H magnetic resonance spectroscopy, cognitive function, and apolipoprotein E genotype in normal aging, mild cognitive impairment and Alzheimer's disease.Semantic proximity Read ↗

Effects of normal aging and SCN1A risk-gene expression on brain metabolites: evidence for an association between SCN1A and myo-inositol.Semantic proximity Read ↗

Baseline predictors of rates of hippocampal atrophy in mild cognitive impairment.Semantic proximity Read ↗

Understanding Proton Magnetic Resonance Spectroscopy Neurochemical Changes using Alzheimer’s Disease Biofluid, PET, Postmortem Pathology Biomarkers and APOE GenotypeSemantic proximity Read ↗

APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain.Semantic proximity Read ↗

Evidence for distinct neuro-metabolic phenotypes in humans.Semantic proximity Read ↗

Understanding Proton Magnetic Resonance Spectroscopy Neurochemical Changes Using Alzheimer's Disease Biofluid, PET, Postmortem Pathology Biomarkers, and APOE Genotype.Semantic proximity Read ↗

MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.