Article
Effects of a functional variant c.353T>C in snai1 on risk of two contextual diseases. Chronic obstructive pulmonary disease and lung cancer.
American journal of respiratory and critical care medicine - 15 Jan 2014
Yang Lei, Yang Xiaorong, Ji Weidong, Deng Jieqiong, Qiu Fuman, Yang Rongrong, Fang Wenxiang, Zhang Lisha, Huang Dongsheng, Xie Chenli, Zhang Haibo, Zhong Nanshan, Ran Pixin, Zhou Yifeng, Lu Jiachun
Abstract excerpt
RATIONALE: Epithelial-mesenchymal transition (EMT) plays a key role in the development of chronic obstructive pulmonary disease (COPD) and lung cancer. OBJECTIVES: There are five major EMT regulatory genes (Snai1, Slug, Zeb1, Zeb2, and Twist1) involved in EMT. We hypothesized that germline variants in these genes may influence the development of both diseases. METHODS: Seven genetic variants were genotyped in two...
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