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Article

Hepatitis C virus impairs natural killer cell-mediated augmentation of complement synthesis.

Journal of virology - 1 Mar 2014

Kim Hangeun, Bose Sandip K, Meyer Keith, Ray Ranjit

Abstract excerpt

UNLABELLED: Natural killer (NK) cells and the complement system play critical roles in the first line of defense against pathogens. The synthesis of complement components C4 and C3 is transcriptionally downregulated by hepatitis C virus (HCV) core and NS5A proteins, and this negative regulation is apparent in chronically HCV-infected patients. In this study, we have examined the potential contribution of an NK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

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Source

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Identifiers

PMID: 24352446
DOI: 10.1128/JVI.02988-13
PMCID: PMC3958077

Genes

MICA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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