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Article

Transcriptional Repression of C4 Complement by Hepatitis C Virus Proteins

24 Feb 2011

Abstract excerpt

The fourth component of human complement (C4) plays an important role in innate immune function. C4 activity has been observed to be significantly lower in patients with chronic hepatitis C virus (HCV) infections, although the mechanism remains unknown. In this study, we have examined the mechanisms of C4 regulation by HCV. Liver biopsy specimens from patients with chronic HCV infections displayed significantly...

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PMID: 21345967
DOI: 10.1128/jvi.02449-10

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