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Article

Contribution of phenotypic heterogeneity to adaptive antibiotic resistance.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014

Sánchez-Romero María Antonia, Casadesús Josep

Abstract excerpt

Antibiotic-resistant isolates of Salmonella enterica were selected on plates containing lethal concentrations of rifampicin, kanamycin, and nalidixic acid. The stability of the resistance phenotype was scored after nonselective growth. Rifampicin-resistant (Rif(r)) isolates were stable, suggesting that they had arisen by mutation. Mutations in the rpoB gene were detected indeed in Rif(r) mutants. In contrast, a...

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Identifiers

PMID: 24351930
DOI: 10.1073/pnas.1316084111
PMCID: PMC3890857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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