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Article

Adaptation and preadaptation of Salmonella enterica to Bile.

PLoS genetics - 1 Jan 2012

Hernández Sara B, Cota Ignacio, Ducret Adrien, Aussel Laurent, Casadesús Josep

Abstract excerpt

Bile possesses antibacterial activity because bile salts disrupt membranes, denature proteins, and damage DNA. This study describes mechanisms employed by the bacterium Salmonella enterica to survive bile. Sublethal concentrations of the bile salt sodium deoxycholate (DOC) adapt Salmonella to survive lethal concentrations of bile. Adaptation seems to be associated to multiple changes in gene expression, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22275872
DOI: 10.1371/journal.pgen.1002459
PMCID: PMC3261920

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