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Article

Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity.

Science (New York, N.Y.) - 21 Apr 2017

Bergmiller Tobias, Andersson Anna M C, Tomasek Kathrin, Balleza Enrique, Kiviet Daniel J, Hauschild Robert, Tkačik Gašper, Guet Călin C

Abstract excerpt

The molecular mechanisms underlying phenotypic variation in isogenic bacterial populations remain poorly understood. We report that AcrAB-TolC, the main multidrug efflux pump of Escherichia coli, exhibits a strong partitioning bias for old cell poles by a segregation mechanism that is mediated by ternary AcrAB-TolC complex formation. Mother cells inheriting old poles are phenotypically distinct and display...

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Identifiers

PMID: 28428424
DOI: 10.1126/science.aaf4762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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