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Article

Multidrug Resistance and Cancer Stem Cells in Neuroblastoma and Hepatoblastoma

18 Dec 2013

Abstract excerpt

Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could explain the up-regulation of MDR genes/proteins in cancer after chemotherapy. It is known that cancer stem cells (CSCs) play a role as master regulators. Therefore, understanding the mechanisms that regulate some traits of CSCs may help...

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PMID: 24351843
DOI: 10.3390/ijms141224706

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