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Article

Methylphenidate side effect profile is influenced by genetic variation in the attention-deficit/hyperactivity disorder-associated CES1 gene.

Journal of child and adolescent psychopharmacology - 1 Dec 2013

Johnson Katherine A, Barry Edwina, Lambert David, Fitzgerald Michael, McNicholas Fiona, Kirley Aiveen, Gill Michael, Bellgrove Mark A, Hawi Ziarih

Abstract excerpt

OBJECTIVE: A naturalistic, prospective study of the influence of genetic variation on dose prescribed, clinical response, and side effects related to stimulant medication in 77 children with attention-deficit/hyperactivity disorder (ADHD) was undertaken. The influence of genetic variation of the CES1 gene coding for carboxylesterase 1A1 (CES1A1), the major enzyme responsible for the first-pass, stereoselective...

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Source

Identifiers

PMID: 24350812
DOI: 10.1089/cap.2013.0032

Genes

CES1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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