Article
Association of a carboxylesterase 1 polymorphism with appetite reduction in children and adolescents with attention-deficit/hyperactivity disorder treated with methylphenidate.
The pharmacogenomics journal - 1 Oct 2013
Bruxel E M, Salatino-Oliveira A, Genro J P, Zeni C P, Polanczyk G V, Chazan R, Rohde L A, Hutz M H
Abstract excerpt
Carboxylesterase 1 is the enzyme involved in methylphenidate (MPH) metabolism. The aim of this study was to evaluate the association between a -75 T>G polymorphism and appetite reduction in children with attention-deficit/hyperactivity disorder (ADHD). A sample of 213 children with ADHD was investigated. The primary outcome was appetite reduction measured by the Barkley Stimulant Side Effect Rating Scale applied...
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