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Article

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice.

Molecular neurobiology - 1 Jun 2014

Lopes Carla, Ribeiro Márcio, Duarte Ana I, Humbert Sandrine, Saudou Frederic, Pereira de Almeida Luís, Hayden Michael, Rego A Cristina

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant disease caused by an expansion of CAG repeats in the gene encoding for huntingtin. Brain metabolic dysfunction and altered Akt signaling pathways have been associated with disease progression. Nevertheless, conflicting results persist regarding t...

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Identifiers

PMID: 24347322
DOI: 10.1007/s12035-013-8585-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24347322-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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