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Article

Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy.

Neuron - 13 Aug 2009

Palazzolo Isabella, Stack Conor, Kong Lingling, Musaro Antonio, Adachi Hiroaki, Katsuno Masahisa, Sobue Gen, Taylor J Paul, Sumner Charlotte J, Fischbeck Kenneth H, Pennuto Maria

Abstract excerpt

Expansion of a polyglutamine tract in the androgen receptor (AR) causes spinal and bulbar muscular atrophy (SBMA). We previously showed that Akt-mediated phosphorylation of AR reduces ligand binding and attenuates the mutant AR toxicity. Here, we show that in culture insulin-like growth factor 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19679072
DOI: 10.1016/j.neuron.2009.07.019
PMCID: PMC2735765

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19679072-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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