Article
Glioblastoma cell enrichment is critical for analysis of phosphorylated drug targets and proteomic-genomic correlations.
Cancer research - 1 Feb 2014
Mueller Claudius, deCarvalho Ana C, Mikkelsen Tom, Lehman Norman L, Calvert Valerie, Espina Virginia, Liotta Lance A, Petricoin Emanuel F
Abstract excerpt
The quality of cancer genomic and proteomic data relies upon the quality of the clinical specimens examined. Here, we show that data derived from non-microdissected glioblastoma multiforme tumor tissue is either masked or not accurate, producing correlations between genomic and proteomic data that lead to false classifications for therapeutic stratification. We analyzed the level of 133 key signaling proteins and...
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