Article
Protein patterns and proteins that identify subtypes of glioblastoma multiforme.
Oncogene - 2 Sept 2004
Furuta Makoto, Weil Robert J, Vortmeyer Alexander O, Huang Steve, Lei Jingqi, Huang Tai-Nan, Lee Youn-Soo, Bhowmick Deb A, Lubensky Irina A, Oldfield Edward H, Zhuang Zhengping
Abstract excerpt
Glioblastoma multiforme (GBM) has been subdivided into two types based on clinical and genetic findings: primary tumors, which arise de novo, and secondary tumors, which progress from lower grade gliomas to GBMs. To analyse this dichotomy at the protein level, we employed selective tissue microdissection to obtain pure populations of tumor cells, which we studied using two-dimensional protein gel electrophoresis...
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