Article
Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers.
PloS one - 1 Jan 2014
Schleifman Erica B, Desai Rupal, Spoerke Jill M, Xiao Yuanyuan, Wong Cheryl, Abbas Ilma, O'Brien Carol, Patel Rajesh, Sumiyoshi Teiko, Fu Ling, Tam Rachel N, Koeppen Hartmut, Wilson Timothy R, Raja Rajiv, Hampton Garret M, Lackner Mark R
Abstract excerpt
Patients with newly diagnosed, early stage estrogen receptor positive (ER+) breast cancer often show disease free survival in excess of five years following surgery and systemic adjuvant therapy. An important question is whether diagnostic tumor tissue from the primary lesion offers an accurate molecular portrait of the cancer post recurrence and thus may be used for predictive diagnostic purposes for patients...
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