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Article

Adolescence: a time of transition for the phenotype of dcc heterozygous mice.

Psychopharmacology - 1 Apr 2014

Yetnikoff Leora, Pokinko Matthew, Arvanitogiannis Andreas, Flores Cecilia

Abstract excerpt

RATIONALE: Stark differences exist between adult (>PND 70) and juvenile (∼PND 21-34) rodents in how DCC (deleted in colorectal cancer) receptors and sensitization to amphetamine interact. In adults, repeated amphetamine upregulates DCC receptor expression selectively in the ventral tegmental area (VTA), an effect that is critical for sensitization. In contrast, amphetamine administered to juveniles downregulates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23572211
DOI: 10.1007/s00213-013-3083-z

Genes

DCC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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