Article
A distinct physiological role of MutY in mutation prevention in mycobacteria.
Microbiology (Reading, England) - 1 Jan 2010
Kurthkoti Krishna, Srinath Thiruneelakantan, Kumar Pradeep, Malshetty Vidyasagar S, Sang Pau Biak, Jain Ruchi, Manjunath Ramanathapuram, Varshney Umesh
Abstract excerpt
Oxidative damage to DNA results in the occurrence of 7,8-dihydro-8-oxoguanine (8-oxoG) in the genome. In eubacteria, repair of such damage is initiated by two major base-excision repair enzymes, MutM and MutY. We generated a MutY-deficient strain of Mycobacterium smegmatis to investigate the role of this enzyme in DNA repair. The MutY deficiency in M. smegmatis did not result in either a noteworthy susceptibility...
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