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Article

Characterization of T-5 N-oxide formation as the first highly selective measure of CYP3A5 activity.

Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2014

Li Xiaohai, Jeso Valer, Heyward Scott, Walker Gregory S, Sharma Raman, Micalizio Glenn C, Cameron Michael D

Abstract excerpt

Almost half of prescription medications are metabolized by cytochrome P450 3A4 and 3A5. CYP3A4 and 3A5 have significant substrate overlap, and there is currently no way to selectively monitor the activity of these two enzymes, which has led to the erroneous habit of attributing the cumulative activity to CYP3A4. While CYP3A4 expression is ubiquitous, CYP3A5 expression is polymorphic, with large individual...

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Identifiers

PMID: 24335391
DOI: 10.1124/dmd.113.054726
PMCID: PMC3935135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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