Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the β-Catenin/TCF/LEF-1 pathway in gastric cancer cells.

Nucleic acids research - 1 Mar 2014

Tang Xiaoli, Zheng Dong, Hu Ping, Zeng Zongyue, Li Ming, Tucker Lynne, Monahan Renee, Resnick Murray B, Liu Manran, Ramratnam Bharat

Abstract excerpt

Glycogen synthase kinase 3 beta (GSK3β) is a critical protein kinase that phosphorylates numerous proteins in cells and thereby impacts multiple pathways including the β-Catenin/TCF/LEF-1 pathway. MicroRNAs (miRs) are a class of noncoding small RNAs of ∼22 nucleotides in length. Both GSK3β and mi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to beta Catenin
Share to Glycogen Synthase Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3 beta

Share to Lymphoid Enhancer-Binding Factor 1

Share to Stomach Neoplasms

Share to TCF Transcription Factors

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 24335145
DOI: 10.1093/nar/gkt1275
PMCID: PMC3950676

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24335145-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the β-Catenin/TCF/LEF-1 pathway in gastric cancer cells.PMID 24335145Read ↗

Deregulated GSK3 Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and TelomeraseSemantic proximity Read ↗

Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy.Semantic proximity Read ↗

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer.Semantic proximity Read ↗

Proteomic characterization of GSK3β knockout shows altered cell adhesion and metabolic pathway utilisation in colorectal cancer cells.Semantic proximity Read ↗

miR-181a modulates proliferation, migration and autophagy in AGS gastric cancer cells and downregulates MTMR3Semantic proximity Read ↗

Kinase-Inactive Glycogen Synthase Kinase 3β Promotes Wnt Signaling and Mammary TumorigenesisSemantic proximity Read ↗

Glycogen synthase kinase 3beta induces apoptosis in cancer cells through increase of survivin nuclear localization.Semantic proximity Read ↗

Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinomaSemantic proximity Read ↗

Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progressionSemantic proximity Read ↗

Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor κB target genes and induction of apoptosis in chronic lymphocytic leukemia B cellsSemantic proximity Read ↗

MicroRNA‐103a inhibits gastric cancer cell proliferation, migration and invasion by targeting c‐MybSemantic proximity Read ↗

Recent advances in understanding the cellular roles of GSK-3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.