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Article

Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma

1 Jan 2011

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is a malignant cancer with an observable heterogeneity and microRNAs are functionally associated with the tumorigenesis of HCC. We recently identified that EpCAM (CD326)-positive cells isolated from alpha-fetoprotein (AFP)-positive HCC samples are hepatic cancer stem cells (HepCSCs). EpCAM+AFP+ HepCSCs have an activated Wnt/β-catenin signaling with a parallel increased...

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PMID: 21711587
DOI: 10.1186/2045-3701-1-4

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